pentobarbital will lower the extent or influence of etravirine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of.
pentobarbital will minimize the extent or influence of itraconazole by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Not known.
Warning when discontinuing CYP3A4 inducers which have been coadministered with hydrocodone; plasma concentrations of hydrocodone may possibly enhance and can lead to potentially lethal respiratory depression
fentanyl transmucosal and pentobarbital both equally enhance sedation. Prevent or Use Alternate Drug. Limit use to patients for whom alternate treatment method selections are insufficient
pentobarbital will minimize the level or influence of tadalafil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on. Stay away from mixture in pulmonary HTN clients. For clients with ED, watch response to tadalafil very carefully as a consequence of potential for diminished efficiency.
pentobarbital will decrease the level or outcome of iloperidone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.
CYP3A4 inducers could improve the formation with the neurotoxic/nephrotoxic ifosfamide metabolite, chloroacetaldehyde. Intently observe patients having ifosfamide with CYP3A4 inducers for toxicities and take into account dose adjustment.
Monitor Intently (one)pentobarbital will decrease read more the level or influence of cannabidiol by influencing hepatic/intestinal enzyme CYP3A4 metabolism.
pentobarbital will lower the extent or result of stiripentol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. If not able to stay away from coadministration of stiripentol with strong CYP3A4 inducers, raise stiripentol dose.
pentobarbital will reduce the level or outcome of estradiol vaginal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.
pentobarbital will reduce the level or result of tamoxifen by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor.
Keep track of Closely (three)pentobarbital will minimize the extent or result of diazepam intranasal by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of. Robust or average CYP3A4 inducers could enhance level of diazepam elimination; consequently, efficacy of diazepam can be diminished.
Barbiturates can induce hepatic microsomal enzymes resulting in enhanced metabolism and lowered anticoagulant response of oral anticoagulants (eg, warfarin, acenocoumarol, dicumarol, and phenprocoumon); patients stabilized on anticoagulant therapy may well need dosage changes if barbiturates are included to or withdrawn from their dosage program
Comment: Barbiturates may perhaps improve adverse effects, which includes respiratory despair, made by poisonous doses of TCAs. With therapeutic doses of TCAs, barbiturates enhance metabolism and decrease blood concentrations of TCAs.