pentobarbital will lower the extent or influence of etravirine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of.pentobarbital will minimize the extent or influence of itraconazole by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Not known.Warning when discontinuing CYP3A4 inducers whi